Since 2016, the GDCh Division of Biochemistry has been awarding the Young Scientist Award Biochemistry to recognize outstanding research achievements in the field of biochemistry - proven either by a dissertation or an original publication in a scientific journal. The award comes with an award certificate and prize money of 2,000 euros. The award is decided by a panel of experts appointed by the Division Board . From 2024, up to two prizes will be awarded per year.
Deadline: April 30, 2025
objective
The Division of Biochemistry of the German Chemical Society (GDCh) will award up to two research prizes for 2025 to recognize outstanding research achievements in the field of biochemistry – to be demonstrated either by a dissertation or a selected original publication in a scientific journal.
The price
Each award is accompanied by a certificate and prize money of 2,000 euros. The prizes will be awarded the following year during the GDCh Biochemistry 2026 Division conference , which will take place in Würzburg. The awardee will be invited to present their award-winning work in a short lecture. The costs for attending the conference will be borne by the Division. The award winners will be decided by a panel of experts appointed by the Division Board .
nomination/application
Nominations can be made by the academic supervisor, but applications are also possible. The academic publication must be published between January 1 and December 31, 2024; the doctoral examination must be no more than 4 years old at the time of publication. The dissertation must be completed in 2024 (including defense). All proposals consist of a brief justification of the academic supervision, the CV of the nominee (including contact details) and the academic work itself.
submission
Please send your suggestions in electronic form and summarized in a PDF file to the GDCh Office for the attention of Maike Fries.
For the first time in 2024, the Division of Biochemistry of the German Chemical Society awarded two fully endowed prizes. These were presented to Dr. Davide Tamborrini and Dr. Minh Nguyen Trung on October 1, 2024, at Biochemistry 2024 in Dortmund.
Dr. Davide Tamborrini: "Awarded in recognition of his dissertation entitled “Structural Investigation of the Relaxed Cardiac Sarcomere by Electron Cryo-Tomography” written in the working group of Prof. Dr. Stefan Raunser at the Max Planck Institute for Molecular Physiology in Dortmund. Dr. Tamborrini determined high-resolution structures of native thick myosin filaments in mouse cardiac muscle, answering decades-old questions. The structures revealed the three-dimensional organization of myosin, titin, and myosin-binding protein C (MyBP-C), and showed that MyBP-C bridges thin and thick filaments. The arrangement of the proteins is completely different from predictions and explains important mechanistic features of muscle contraction and its regulation. The results of his valuable work are paradigmatic and open the door to a new world of muscle research, both to understand how muscles work and to find treatments for diseases."
Dr. Minh Nguyen Trung: "Awarded in recognition of his dissertation working group "Elucidation of Inositol Polyphosphate Dephosphorylation Pathways Using Stable-Isotope Labelling and NMR Spectroscopy" written in the research group of Prof. Dr. Dorothea Fiedler at the Leibniz Research Institute for Molecular Pharmacology in Berlin . Minh Nguyen Trung developed an innovative analytical method that combines targeted 13 C isotope labelling with NMR spectroscopy to decipher inositol phosphate metabolism both biochemically and in complex biological samples. His method closes a technical gap and opens up perspectives for future research in many areas, including research into inositol phosphate-dependent hereditary diseases and the metabolism of the human microbiome. "
The Young Scientist Award of the Division of Biochemistry of the German Chemical Society was split and presented to Dr. Jan Felber and Dr. Wout Oosterheert on September 5, 2023, on the occasion of the GDCh Science Forum on Chemistry in Leipzig.
"The prize is awarded to Dr. Jan Felber in recognition of his dissertation entitled "Rational development of stabilized cyclic disulfide redox probes and bioreductive prodrugs to target dithiol oxidoreductases," which he wrote in the working group of Dr. Oliver Thorn-Seshold at the Ludwig Maximilian University in Munich. Jan Felber has made a significant contribution to a better understanding of enzyme cascades in redox biochemistry through the systematic development of complex disulfide structures and their use for the cellular activation of novel molecular probes by special oxidoreductases. Due to the modularity of the molecular system, his work also promises considerable potential for the use of such disulfide units for the targeted activation of drugs."
"The prize is awarded to Dr. Wout Oosterheert in recognition of his publication entitled “Structural basis of actin filament assembly and aging,” which he prepared in the working group of Prof. Dr. Stefan Raunser at the Max Planck Institute for Molecular Physiology in Dortmund and published in the journal Nature .
In this work, Wout Oosterheert determined high-resolution cryo-EM structures of F-actin in all nucleotide states, which made it possible for the first time to visualize hundreds of water molecules in the filament. His resulting elucidation of the ATP hydrolysis mechanism of F-actin represents a milestone in more than a century of physiological and biochemical muscle and cytoskeleton research. His work also provides the valuable basis for the development of actin-binding molecules that can be tailored for imaging and therapeutic applications. "
The Young Scientist Award of the Division of Biochemistry of the German Chemical Society was split and presented on 30 June 2022 to Dr. Goran Kokic and Dr. Sabrina Pospich at the Division conference “Biochemistry 2022” in Münster.
"The prize is awarded to Dr. Goran Kokic in recognition of his publication entitled "Structural basis of human transcription - DNA repair coupling" Nature 2021, 598, 368, which was prepared in the working group of Prof. Dr. Patrick Cramer at the Max Planck Institute for Biophysical Chemistry in Göttingen and published in the journal Nature. This work is particularly notable for the fact that, for the first time, detailed structural insights into the molecular coupling of gene transcription with DNA repair in eukaryotic cells were obtained. In particular, biochemical and cryo-electronic investigations of large transient multiprotein nucleic acid complexes were combined in such a way that a multi-stage molecular model for transcription-repair coupling could be created. The work is also relevant for adjacent research fields. For example, initial insights into the structural basis of ubiquitination of a large multiprotein complex substrate were obtained, thus laying the foundation for further Investigation of the regulation of transcription-repair coupling."
"The prize is awarded to Dr. Sabrina Pospich in recognition of her dissertation entitled "Deciphering the structural effect of nucleotide hydrolysis and small molecule binding on actin and myosin" written in the working group of Prof. Dr. Stefan Raunser at the Max Planck Institute for Molecular Physiology in Dortmund. In her doctoral thesis, Ms. Pospich used cryo-electron microscopy to investigate the proteins actin and myosin, two elementary components of the cytoskeleton and muscle. She skillfully determined a large number of high-resolution three-dimensional structures of actin filaments with various ligands or myosin and was thus able to gain important insights into biologically and medically relevant issues. Her work makes a decisive contribution to the molecular understanding of cardiomyopathies and other muscle diseases."
The 2020 Young Scientist Award of the Division of Biochemistry of the German Chemical Society was shared and presented to Maximilian Fottner and Dr. Marc-André Kasper at the “Advances in Chemical Biology” Conference on January 27, 2021 in Frankfurt.
The prize is awarded to Mr. Maximilian Fottner in recognition of his publication entitled: “Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase”. In his doctoral thesis, Maximilian Fottner dealt with innovative and interdisciplinary strategies for the site-specific modification of proteins. In his award-winning work, Mr. Fottner developed a groundbreaking and promising method for the targeted and selective labeling of proteins – both in vitro and in living mammalian cells – with the small marker protein ubiquitin. In doing so, he succeeded in developing an extremely powerful tool for analyzing the biological functions and consequences of these extremely important post-translational modifications.
The prize is awarded to Dr. Marc-André Kasper in recognition of his dissertation on the subject of “Chemoselective synthesis of functional drug conjugates”. In his work, Dr. Kasper was able to develop a new cysteine-selective reaction for the modification of antibodies, known as P5 labeling. Using this process, he produced a new antibody-drug conjugate that has better efficacy and stability properties than an already approved drug.
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last modified: 12.12.2024 16:32 H from C.Kniep
