Manfred T. Reetz

Abstract by Prof. Dr. Dr. hc Manfred T. Reetz

Evolution in the Test Tube: An Abundant Catalyst Source for Stereoselective Reactions

Since the first report on directed evolution of stereoselective enzymes as a new catalyst source in organic chemistry and Biotechnology [1], the underlying concept has been generalized to include almost all enzyme types: hydrolases (e.g. lipases, esterases, epoxide hydrolases, glycosidases), monooxygenases (e.g. P450, Baeyer-Villiger enzymes), reductases (e.g. alcohol dehydrogenases, enoate reductases), and CC linkage enzymes (e.g. aldolases, oxynitrilases). [2,3] Repetitive cycles of gene mutagenesis and screening form the basis of this Darwinian approach, because ?evolutionary pressure? is exerted in each round with a concomitant increase in enantioselectivity. Since the screening step is labor intensive, we have recently developed efficient methods to generate small but ?intelligent? mutant libraries. [2-5] The applications are particularly interesting when it comes to selective material conversions that cannot be achieved with modern synthetic reagents, transition metal catalysts or organocatalysts. [5]
[1] MT Reetz et al., Angew. Chem. Int. Ed. 1997, 36, 2830-2832.
[2] Review of directed evolution of stereoselective enzymes: MT Reetz, Angew. Chem. Int. Ed. 2011, 50, 138-174.
[3] Perspectives article on biocatalysis in organic chemistry: MT Reetz, J. Am. Chem. Soc. 2013, 135, 12480-12496.
[4] Review of recent method developments in the field of directed evolution: MT Reetz et al., Chem. Eur. J. 2016, 22, 5046-5054.
[5] Directed evolution of enantioselective alcohol dehydrogenases for the asymmetric reduction of ?difficult? ketones: MT Reetz et al., ACS Catal. 2016, 6, 1598-1605.

Curriculum Vitae of Prof. Dr. Dr. hc Manfred T. Reetz

2011 from September 1st emeritus status and Hans Meerwein research professor at the Philipps University of Marburg or external group leader of the Max Planck Institute
1993-2011 Managing Director of the Studiengesellschaft Kohlen mbH, SGK (patent department of the institute)
1993-2002 Managing Director of the Max Planck Institute for Coal Research
1992-2010 Honorary professor at the Ruhr University Bochum
1991-2011 Director at the Max Planck Institute for Coal Research
1989-1990 Visiting Professor at Florida State University (USA)
1980-1991 C4 professor at the University of Marburg
1978-1980 C3 professor at the University of Bonn
1978 Visiting professor at the University of Wisconsin (USA)
1972-1988 Habilitation University of Marburg
1971-1972 Postdoc University of Marburg (RW Hoffmann)
1969 Doctorate, University of Göttingen (U. Schöllkopf)
1967 Master, University of Michigan, Ann Arbor / USA
1965 Bachelor, Washington University, St. Louis, USA
1952 Emigration to the USA
1943 Born August 13, 1943 in Hirschberg / Silesia

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last modified: 10.05.2021 15:39 H from