Moderation: Klaus-Peter Jäckel
At the turn of the century it was hardly possible for women to penetrate the domains of men. Abitur and university studies were largely a male privilege. With acquired knowledge, a lot of persistence, a high degree of moral courage and immense hard work, some women achieved the highest educational qualifications. Not infrequently they came from wealthy families and often had male colleagues as sponsors. Some women worked as teachers, but only a few found their way into the natural sciences. Today we will talk about such strong women who have left their mark on the natural sciences - but also about women who failed and whose life-long work was not recognized and appreciated.
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Moderation: still open
Diabetes is a widespread disease. Around 10% of German citizens and around 6% of the world population suffer from it. The basics of the disease, the consequential damage as well as the treatment options and therapy goals are discussed.
The peptide hormone insulin plays the central role in this disease. The discovery of the hormone, its structure elucidation and other milestones in 100 years of insulin research are presented. Based on an estimate of the demand for insulin, various possibilities for its industrial production are addressed, especially biotechnological. The terms 'genetic engineering' and 'biotechnology' are defined.
The genetic engineering of human insulin is a success story. The large-scale production is illustrated using the example of the production of human insulin in E. coli strains; the main features of biotechnological processes and protein biosynthesis are explained.
The genetic engineering of insulin analogues led to the availability of new active substance molecules with an improved profile of action for diabetics. In addition, newer therapeutic approaches for the treatment of diabetes are presented. Some aspects of the topic ?How does pharmaceutical research work?? Are dealt with.
last modified: 01.12.2021 17:58 H from W.Gerhartz