Since 2016, the GDCh Division of Biochemistry has generally awarded the Young Scientist Award Biochemistry annually to recognize outstanding research achievements in the field of biochemistry - as evidenced by a dissertation or a publication in a scientific journal. The award is combined with an award certificate and prize money of 2000 euros. An expert committee appointed by the Division Board board decides on the award of the prize. The prize can be shared.
The 2020 advancement Young Scientist Award of the Division of Biochemistry of the German Chemical Society was awarded to Maximilian Fottner and Dr. Marc-André Kasper was awarded at the Division conference "Advances in Chemical Biology" on January 27, 2021 in Frankfurt.
The prize is awarded to Mr. Maximilian Fottner in recognition of his publication with the title: ?Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase?. In his doctoral thesis, Maximilian Fottner dealt with innovative and interdisciplinary strategies for the position-specific modification of proteins. In the award-winning thesis, Mr. Fottner developed a pioneering and promising method to provide proteins - both in vitro and in living mammalian cells - with the small marker protein ubiquitin. This enabled him to develop an extremely powerful tool for analyzing the biological functions and consequences of these extremely important post-translational modifications.
The award is given to Dr. Marc-André Kasper awarded in recognition of his dissertation with the topic: "Chemoselective synthesis of functional drug conjugates". In his work, Dr. Kasper developed a new cysteine-selective reaction for the modification of antibodies, the so-called P5-labeling. Using this process, he produced a new antibody-drug conjugate that has better active and stable properties than an already approved drug.
The 2019 advancement Young Scientist Award of the Division of Biochemistry of the German Chemical Society was awarded to Dr. Karolin Wellner, Dr. Andreas Blees and Dr. Dennis Quentin was awarded at the GDCh Science Forum 2019 in Aachen on September 16, 2019.
Dr. In her doctoral thesis "For the functional analysis of the 3 'end of tRNAs and the importance of ribonucleases for quality control", Wellner examined the interplay of opposing enzyme activities that are involved in the processing or degradation of tRNAs. The opposite activities of CCA-adding enzyme and RNase T have previously been described as useless circulation. Ms. Wellner was able to show in very elegant experiments that these activities provide an important interaction in tRNA quality control. She is an excellent experimenter and interprets her data extremely carefully and free of any "overselling" - an important quality for a serious scientist.
The award is given to Dr. Quentin awarded in recognition of his dissertation on the topic: "Structural studies on the Type VI secretion system and human CLN3p". Both his work on the human CLN3 protein and the newly gained insights into the bacterial type 6 secretion system that Dr. Quentin delivered by means of cryo-electron microscopy make a decisive contribution to the molecular understanding of child dementia NCL and bacterial infections. The dissertation was carried out in the working group of Prof. Dr. Stefan Raunser at the Max Planck Institute for Molecular Physiology in Dortmund.
Dr. Andreas Blees in recognition of his publication with the topic: ?Structure of the human MHC-I peptide-loading complex?. The adaptive immune system is responsible for recognizing malignant or infected cells. Malfunction can lead to chronic inflammation and autoimmune diseases. Dr. Using innovative strategies, Blees succeeded in preparing the antigen transport and loading complex responsible for immune recognition and thus elucidating its structure. These trend-setting insights will find their way into textbooks as they decisively enrich our understanding of the cellular immune defense.
The 2018 Young Scientist Award from the Division of Biochemistry of the German Chemical Society was awarded to Dr. Doreen Könning and Dr. Schara Safarian at the international Conference "8th Peptide Engineering Meeting" (PEM 8) in Berlin on November 9, 2018.
Dr. In her doctorate ?Engineered shark antibody domains for biotechnological and biomedical applications?, Könning carried out pioneering research at the interface between biochemistry, pharmaceutical research and immunobiology. She developed processes for the production of tailor-made antibodies that open up new possibilities in drug production, medical diagnostics and cancer therapy. Her research approach, in particular, significantly simplifies the isolation of binding molecules for diagnostic applications and also creates the basis for new therapeutic approaches in personalized immunotherapy.
Dr. Safarian made in his promotion "Structure of a bd oxidase indicates similar mechanisms for membrane-integrated oxygen reductases" pioneering research at the interface between biochemistry and structural biology His work for crystallization and structure determination of microbial cytochrome bd oxidase provide new insights into the structure and function. This protein complex is of fundamental importance in bioenergetics and plays an important role in the pathogenicity of bacterial pathogens. With his work, Dr. Safarian created an essential knowledge base for the structure-based development of active ingredients for the treatment of bacterial infections.
The 2017 advancement Young Scientist Award of the Division of Biochemistry of the German Chemical Society was awarded to Dr. Josephin Marie Holstein and Dr. Jian Lei was awarded on the occasion of the GDCh Science Forum on September 13, 2017 in Berlin.
Dr. In her doctoral thesis ?The 5 'cap of eukaryotic mRNAs as a starting point for chemo-enzymatic markings?, Holstein did pioneering research at the interface between chemistry and biology . Ms. Holstein's new approach makes it possible to mark messenger RNA (mRNA) in a highly selective and sequence-independent manner in vitro and in cells or to specifically influence the function of mRNA. Ms. Holstein discovered a methyl transferase (Ecm1) with a pronounced substrate promiscuity and developed new S-adenosyl-L-methionine analogues, so that mRNA is now accessible for post-synthetic modification and intracellular bioorthogonal reactions.
With his publication on the topic: ?Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor?, Jian Lei carried out pioneering research at the interface between biochemistry, structural biology and pharmaceutical chemistry. His work on the structure elucidation of viral proteases enables new insights into their structure and function. In particular, his research on the structure elucidation of the NS2B / NS3 protease from the Zika virus enables a detailed insight into the processing of the viral polyprotein and creates an essential knowledge base for the structure-based development of active ingredients for the treatment of viral infections.
The 2016 Young Scientist Award from the Division of Biochemistry of the German Chemical Society was awarded to Dr. Marie-Luise Winz in recognition of her doctorate on the subject of "Biological, chemical and computational investigations on RNA function and modification" at the "Shaping the Molecules of Life" Conference on July 7, 2016.
Marie-Luise Winz has done pioneering research at the interface between biology, chemistry and computer science . Her work on the isolation and sequence analysis of chemically modified ribonucleic acids from biological sources led to the discovery of coenzyme-capped regulatory RNAs in bacteria. In addition, Ms. Winz gained fundamental knowledge about the course of in vitro evolution experiments and developed new methods for labeling nucleic acids.
|2020||Maximilian Fottner||Technical University of Munich||publication|
|Dr. Marc-André Kasper||Leibniz Research Institute for Molecular Pharmacology, Berlin||dissertation|
|2019||Dr. Andreas Blees||University of Frankfurt||publication|
|Dr. Dennis Quentin||MPI for Molecular Physiology, Dortmund||dissertation|
|Dr. Karolin Wellner||University of Leipzig||dissertation|
|2018||Dr. Doreen Könning||TU Darmstadt||dissertation|
|Dr. Sharah Safarian||MPI Frankfurt||dissertation|
|2017||Dr. Josephin Holstein||University of Munster||dissertation|
|Dr. Jian Lei||University of Lübeck||publication|
|2016||Dr. Marie-Luise Winz||University of Heidelberg||dissertation|
last modified: 04.05.2021 19:09 H from C.Kniep